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30fivebio.com: The GPR35 Antagonist Play
A lean biotech building a gut shield for colitis patients.
While big pharma chases crowded targets, ThirtyFiveBio is quietly building a specialized shield for the gut epithelium. Their focus: genetically-validated GPCR GPR35 antagonists for colitis.
"In a sector defined by bloat, ThirtyFiveBio proves that specialized, founder-led science can move faster than the giants."
The Genetic Validation Edge
ThirtyFiveBio isn't chasing novel biology; they're exploiting known genetics. By targeting GPR35—a receptor with strong genetic links to inflammatory bowel disease—they reduce clinical risk. This isn't a 'shot in the dark' approach; it's a calculated strike on a validated pathway.
The Lean Biotech Model
With just 22 employees and $1.7M in revenue, ThirtyFiveBio operates with extreme capital efficiency. They aren't burning cash on massive infrastructure. Instead, they're leveraging specialist knowledge to develop small molecule antagonists, likely using CROs for heavy lifting while keeping core IP and strategy in-house.
The team composition tells the story: a mix of CEO leadership (James Westcott, Kirsty McCarthy) and deep scientific advisory from co-founders like Stuart Hughes and Peter Joyce. It's a structure built for agility—executives steering the ship, scientists ensuring the chemistry is sound.
- Genetically-validated target (GPR35) reduces clinical failure risk
- Small molecule approach allows for oral administration potential
- Focused on gut epithelial shield mechanism for colitis
- Lean team structure minimizes burn rate while maximizing IP ownership
The Quiet Contender
ThirtyFiveBio represents the modern biotech archetype: small, focused, and scientifically rigorous. For investors, the question isn't whether they have the resources—it's whether they have the right target. GPR35 suggests they do.
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Applying specialist knowledge to develop small molecule antagonists of genetically-validated GPCR GPR35.
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About 30fivebio.com
Applying specialist knowledge to develop small molecule antagonists of genetically-validated GPCR GPR35.
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30fivebio.com uses 9 technologies across their website including reCAPTCHA, Webflow, AWS CloudFront, and more.
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