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OpenBiome: The $3.4M Microbiome Frontier
How a nonprofit is turning human waste into a $27K search term opportunity
While most startups chase AI or crypto, OpenBiome is building a literal empire from human waste—and their 22-person team just hit $3.4M in revenue doing it. They're not just selling poop for science; they're solving a $27K keyword problem in healthcare.
"They're monetizing a biological process that most people would pay to avoid."
The $27K Keyword Play
OpenBiome ranks for 'fmt' (Fecal Microbiota Transplantation) with 27,100 monthly searches—a medical procedure that's exploding in popularity. Their organic strategy captures 'human biome project' (1,190 searches) and 'sell poop for science' (100 searches), turning curiosity into clinical revenue. With only 36% organic traffic, they're leaving millions in untapped search volume on the table.
The Trust Paradox
Here's the kicker: 46% of their traffic is direct. People aren't discovering them through SEO—they're typing 'openbiome.org' directly into browsers. That's cult-level brand awareness in a space where trust is everything. When you're handling human fecal matter for medical treatments, direct traffic signals deep institutional relationships and word-of-mouth referrals that money can't buy.
Their tech stack reveals a pragmatic, no-nonsense approach: jQuery, Bootstrap, and Cloudflare. This isn't a flashy Silicon Valley startup burning VC cash on React and microservices. They're using battle-tested tools to deliver a $3.4M service, keeping overhead lean while scaling clinical operations. The 22-person team is surgical in their execution—every hire matters when you're managing donor screening, lab processing, and clinical distribution.
- Direct traffic dominance (46%) shows established B2B relationships, not viral growth
- Keyword strategy targets medical professionals searching for 'fmt' (27K monthly searches)
- Revenue-per-employee of ~$154K indicates efficient operations in a capital-intensive field
- Missing backlink data suggests they're not playing the content marketing game—yet
The Unsexy Billion-Dollar Play
OpenBiome proves that in healthcare, trust beats technology, and clinical relationships beat viral marketing. They're not building for exit—they're building for impact.
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About openbiome.org
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openbiome.org uses 13 technologies across their website including Vimeo, PHP, WordPress, and more.
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openbiome.org receives approximately 8.6K monthly visitors and ranks #1,910,571 globally. The website has a bounce rate of 30% with visitors viewing an average of 3.6 pages per visit. Users spend an average of 0:59 on the site.
The majority of openbiome.org's traffic comes from .
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